This review focuses on the deamidation of asparagine in monoclonal antibodies, one of the well-known degradation pathways.The importance of close monitoring of deamidation from early developability assessment to Makeup Brushes in vivo studies is discussed consequentially.The application of chromatographic and electrophoretic instruments for the sep
Biodriven investigation of the wild edible mushroom Pleurotus eryngii revealing unique properties as functional food
Pleurotus eryngii (P.eryngii) is largely represented among consumed mushrooms.We conducted an investigation dealing with its antioxidant potential, the presence of essential trace elements and its contribution to the management of brain-related disorders.A bio-guided extraction revealed that one extract was highly effective on activation of the nuc
Causal Inference of Carnitine on Blood Pressure and potential mediation by uric acid: A mendelian randomization analysis
Background: Dietary change alters blood pressure (BP) but the specific causal dietary elements are unclear.Given previous observational data suggesting serum carnitine or uric acid affect BP, we investigated the role of serum carnitine and serum uric acid concentrations on BP, and considered mediation by lipids and insulin resistance using two-samp
Dermatological Problems of Brachycephalic Dogs
Brachycephalic dogs are not only affected by brachycephalic obstructive airway syndrome (BOAS), but are also frequently referred to veterinary dermatologists for skin conditions, with English bulldogs and pugs particularly over-represented.Some skin diseases, such as skin fold dermatitis, are directly associated with the abnormal anatomic conformat
Chicken PRMT3 facilitates IBDV replication
ABSTRACT: Protein arginine methyltransferases (PRMTs) in mammals play a role in various signaling pathways, such as virus infection, inflammasome responses, and cancer growth.While some PRMTs have been found to regulate interferon production in mammals, the mechanism in chickens remains to be fully understood.This study focused on investigating the